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. 2022 Jul 4;13:935787. doi: 10.3389/fimmu.2022.935787

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Copyright © 2022 Gluschke, Siegert, Minich, Hackler, Riemekasten, Kuebler, Simmons and Schomburg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prevalence of S1PR–aAb in SSc patients as a function of a diagnosis of PAH. SSc patients were subdivided into those with or without a diagnosis of PAH. (A) Prevalence of S1PR1-aAb was similar in both groups of patients, whereas (B) the prevalence of S1PR2-aAb was higher in SSc patients with PAH than in patients without PAH (P<0.05). (C) The difference in prevalence of S1PR3-aAb between both groups did not reach statistical significance (P>0.05). The binding indices (BI) along with the percentages of positive samples are provided. Prevalence was compared by one-sided Chi square test.