TABLE 3.
Animal behavioral tests representing the effects of ellagic acid (EA) against mild cognitive impairment (MCI).
| Sl./No. | Animal model | EA dosage and treatment duration | Behavioral tests | References |
| I | Streptozotocin-induced MCI | |||
| 1 | Wistar rats | EA (50 mg/kg, p.o.) for 30 days | Y-maze, Radial arm maze | Jha et al., 2018 |
| 2 | Wistar rats | EA (35 mg/kg, p.o.) for 4 weeks | Morris water maze test, Elevated plus maze test | Kumar and Bansal, 2018 |
| II | Lipopolysaccharides-induced MCI | |||
| 1 | Wistar rats | EA (100 mg/kg, p.o.) for 8 days | Open field test, Novel object recognition test | Dornelles et al., 2020 |
| 2 | Wistar rats | EA 218.06 μg/mL: quantitative analysis of Phyllanthus amarus (200 and 400 mg/kg, p.o.) for 14 and 28 days | Novel object recognition test | Alagan et al., 2019 |
| 3 | C57BL/6 mice | Ellagitannin: geraniin (20 mg/kg, p.o.) for 14 days | Morris water maze test | Wang et al., 2019 |
| III | Transgenic animals-induced MCI | |||
| 1 | R6/2 mice | EA (50 and 100 mg/kg, p.o.) for 4 weeks | Novel object recognition test, Y-maze test, Open field test | Sun et al., 2020 |
| 2 | APP/PS1 transgenic mice | EA (50 mg/kg, p.o.) for 60 days | Morris water maze test | Zhong et al., 2018 |
| 3 | ICR mice | EA from persimmon (50 and 100 mg/kg, p.o.) for 3 weeks | Y-maze test, Passive avoidance test, Morris water maze test | Yoo et al., 2021 |
| 4 | ICR mice | Urolithin A-the metabolite of EA (50, 100, and 150 mg/kg, p.o.) for 8 weeks | Morris water maze test, Novel object recognition test | Chen et al., 2019 |
| 5 | APP/PS1 mice | Urolithin A-the metabolite of EA (300 mg/kg, p.o.) for 14 days | Morris water maze test | Gong et al., 2019 |
| IV | Scopolamine- and diazepam-induced MCI | |||
| 1 | Wistar rats | EA (30 and 100 mg/kg, i.p.) for 10 days | Elevated plus-maze test, Passive avoidance test, Open field test | Mansouri et al., 2016 |
| 2 | Wistar rats | EA from Tetrapleura tetraptera and Quassia undulata (50 and 300 mg/kg, p.o.) for 14 days | Novel object recognition test, Y-maze test | Odubanjo et al., 2018 |
| V | Other facts-induced MCI | |||
| 1 | traumatic brain injury (TBI) in rat | EA (100 mg/kg, i.p.) for 3 days | Passive avoidance test | Mashhadizadeh et al., 2017 |
| 2 | Symptoms of HD rats (3-nitropropionic acid) | EA (25, 50, and 100 mg/kg, p.o.) for 21 days | Novel object recognition test, Elevated plus maze test | Sharma et al., 2021 |