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Pathomechanism of both the Olanzapine and Samidorphan drugs. Olanzapine blocks serotonin or dopamine D2 receptors to inhibit extra pyramidal activities. Samidorphan-an opioid receptor antagonist-gets metabolized in the liver and excreted through kidney in urine, contraindicated in patients with liver and kidney disease [[16], [17], [18]].
