Table 1.
Clinical baseline characteristics of patients with hypertrophic obstructive cardiomyopathy with or without atrial fibrillation.
| Hypertrophic obstructive cardiomyopathy with atrial fibrillation (n= 107) | Hypertrophic obstructive cardiomyopathy without atrial fibrillation (n=648) | P-value | |
|---|---|---|---|
| Age (years) | 56.99±11.73 | 50.18±12.81 | <0.001 |
| Female (n, %) | 43 (40.19) | 257 (39.60) | 0.908 |
| BMI (kg/m2) | 26.00±5.10 | 25.73±5.94 | 0.688 |
| Hypertension disease (n, %) | 41 (38.32) | 221 (34.05) | 0.403 |
| Diabetes history (n, %) | 6 (5.61) | 42 (6.47) | 0.729 |
| History of hyperlipidemia (n, %) | 32 (29.90) | 191 (29.43) | 0.935 |
| A clear family history of HCM (n, %) | 9 (8.41) | 40 (6.16) | 0.396 |
| Drinking history (n, %) | 33 (30.84) | 186 (28.66) | 0.680 |
| Smoking history (n, %) | 48 (44.86) | 294 (45.30) | 0.879 |
| Systolic blood pressure (mmHg) | 122.10±18.00 | 120.98±5.94 | 0.563 |
| Diastolic pressure (mmHg) | 74.59±11.47 | 73.90±11.43 | 0.560 |
| Heart rate (b.p.m.) | 71.50±13.13 | 71.69±27.59 | 0.944 |
| LDL-C (mmol/L,x±s) | 2.48±0.89 | 2.35±0.93 | 0.186 |
| HDL-C (mmol/L,x±s) | 0.96±0.30 | 0.97±0.33 | 0.809 |
| Triglyceride (mmol/L,x±s) | 1.59±0.88 | 1.68±0.98 | 0.354 |
| Total cholesterol (mmol/L,x±s) | 4.12±1.11 | 4.02±1.11 | 0.428 |
| NT-proBNP (fmol/mL) | 2476.08±1808.93 | 1814.85±1712.95 | 0.002 |
| Serum creatinine (µmol/L) | 82.77±23.73 | 76.56±20.05 | 0.005 |
| TSH (mIU/L) | 3.02±3.82 | 2.45±4.10 | 0.180 |
| FT4 (ng/dL) | 1.26±0.26 | 1.18±0.23 | 0.002 |
| FT3 (pg/mL) | 2.88±0.59 | 2.99±0.54 | 0.046 |
| TT4 (ng/mL) | 8.00±1.93 | 7.81±1.79 | 0.322 |
| TT3 (ug/dL) | 1.02±0.33 | 1.08±0.29 | 0.092 |
| Echocardiography | |||
| RV end-diastolic diameter (mm) | 21.74±5.77 | 20.28±4.38 | 0.003 |
| LA diameter (mm) | 44.82±8.04 | 39.25±13.28 | 0.001 |
| Interventricular septal thickness (mm) |
19.79±4.52 | 20.27±5.68 | 0.415 |
| LV end-diastolic diameter (mm) | 42.65±6.21 | 42.49±6.02 | 0.801 |
| LV posterior wall thickness (mm) | 11.86±2.77 | 11.94±2.90 | 0.780 |
| LV ejection fraction (%) | 67.07±8.52 | 68.14±8.91 | 0.248 |
| LV outflow tract gradient, at rest (mmHg) | 63.42±32.70 | 74.56±33.42 | 0.002 |
The data in the table is expressed in the form of "mean ±SD" or "n (%)". BMI, body mass index; NT-proBNP, amino terminal pro-brain natriuretic peptide; TSH, thyrotropin; FT3, free triiodothyronine; FT4, free thyroxine; TT3, serum total triiodothyronine; TT4, serum total thyroxine.