Table 2.
General clinical data of patients with different TSH levels.
| TSH level (mlU/L) | P-value | ||||
|---|---|---|---|---|---|
| <0.55 (n=37) | 0.55~2.49 (n=490) | 2.50~9.99 (n=211) | ≥10.00 (n=17) | ||
| Age (years) | 53.79±15.78 | 50.95±12.26 | 50.86±13.82 | 53.31±10.26 | 0.522 |
| Female (n, %) | 20 (54.05) a | 162 (33.06) | 100 (47.39) a | 7 (41.18) | <0.001 |
| BMI (kg/m2) | 25.15±4.44 | 26.16±6.68 | 24.94±3.64 a | 26.38±3.19 | 0.099 |
| Hypertension disease (n, %) | 14 (37.84) | 173 (35.31) | 70 (33.18) | 4 (23.53) | 0.699 |
| Diabetes history (n, %) | 1 (2.70) | 32 (6.53) | 13 (6.16) | 2 (11.76) | 0.637 |
| History of hyperlipidemia (n, %) | 9 (24.32) | 142 (28.98) | 68 (32.23) | 4 (23.53) | 0.672 |
| A clear family history of HCM (n, %) | 2 (5.40) | 32 (6.53) | 13 (6.16) | 2 (11.76) | 0.836 |
| Drinking history (n, %) | 11 (29.73) | 150 (30.61) | 55 (26.07) | 3 (17.65) | 0.450 |
| Smoking history (n, %) | 18 (48.65) | 249 (50.82) | 68 (13.88) a | 7 (41.18) | <0.001 |
| Systolic blood pressure (mmHg) | 122.03±19.83 | 121.43±18.38 | 120.70±18.51 | 117.24±17.94 | 0.803 |
| Diastolic pressure (mmHg) | 72.58±10.36 | 74.17±11.37 | 73.70±11.65 | 75.29±13.40 | 0.797 |
| Heart rate (b.p.m.) | 71.97±13.47 | 72.24±31.11 | 69.92±10.06 | 75.65±22.61 | 0.667 |
| LDL-C (mmol/L,x±s) | 2.09±0.76 | 2.38±0.92 | 2.33±0.92 | 3.10±1.20 | 0.002 |
| HDL-C (mmol/L,x±s) | 0.93±0.32 | 0.97±0.35 | 0.97±0.29 | 1.09±0.33 | 0.415 |
| Triglyceride (mmol/L,x±s) | 1.83±1.41 | 1.66±0.95 | 1.66±0.95 | 1.65±0.43 | 0.792 |
| Total cholesterol (mmol/L,x±s) | 3.80±0.86 | 4.04±1.10 | 3.99±1.11 | 4.84±1.38 a | 0.012 |
| NT-proBNP (fmol/mL) | 2265.36±1910.45 | 1802.25±1625.36 | 2008.33±1841.96 | 2326.71±2364.00 | 0.264 |
| Serum creatinine (µmol/L) | 78.34±28.65 | 77.47±18.88 | 75.92±20.54 | 83.18±19.56 | 0.466 |
| TSH (mIU/L) | 0.29±0.19 a | 1.45±0.51 | 3.73±1.15 a | 23.56±14.68 a | <0.001 |
| FT4 (ng/dL) | 1.38±0.58 a | 1.20±0.18 | 1.16±0.20 a | 0.96±0.26 a | <0.001 |
| FT3 (pg/mL) | 3.25±1.77 a | 3.00±0.38 | 2.91±0.40 a | 2.61±0.45 a | <0.001 |
| TT4 (ng/mL) | 8.22±2.91 | 7.93±1.71 | 7.70±1.54 | 6.32±2.95 a | 0.001 |
| TT3 (ug/dL) | 1.12±0.68 | 1.07±0.26 | 1.05±0.26 | 1.05±0.28 | 0.566 |
| Echocardiography | |||||
| RV end-diastolic diameter (mm) | 21.00±4.83 | 20.61±4.74 | 20.07±4.42 | 20.94±3.42 | 0.457 |
| LA diameter (mm) (mm) | 38.69±9.07 | 39.79±6.66 | 40.67±21.63 | 41.76±5.79 | 0.706 |
| Interventricular septal thickness (mm) |
20.54±7.36 | 20.17±5.29 | 20.16±5.76 | 20.88±5.76 | 0.934 |
| LV end-diastolic diameter (mm) | 45.32±7.20 | 42.87±5.92 | 41.13±5.55 a | 41.88±7.01 a | <0.001 |
| LV posterior wall thickness (mm) | 11.60±2.88 | 11.96±2.83 | 11.93±2.91 | 11.58±3.63 | 0.864 |
| LV ejection fraction (%) | 62.99±14.24 a | 68.36±8.54 | 67.97±7.93 | 70.69±5.28 | 0.002 |
| LV outflow tract gradient, at rest (mmHg) | 71.37±42.35 | 72.886±33.62 | 73.94±32.22 | 71.70±27.65 | 0.968 |
| AF (n, %) | 10 (27.02%) a | 50 (10.20%) | 41 (19.43%) a | 6 (35.29%) a | <0.001 |
a
is compared with TSH 0.55~2.49mIU/L group (normal control group).