Table 1.

Summary of causal association between gut microbial genera and the risk of IBD, UC, or CD by using the IVW method.

Human gut microbiota	N	Traits 1	Traits 2	OR	95%CI	P-value
Clostridium innocuum group	11	CD	\	0.87	0.76-1.00	0.046
Eubacterium ventriosum group	17	UC	IBD	0.68	0.56-0.83	1.00×10-4
Eubacterium eligens group	11	UC	\	1.26	1.00-1.58	0.047
Eubacterium ruminantium group	19	UC	\	1.14	1.00-1.30	0.043
Butyricicoccus	9	UC	\	1.31	1.04-1.64	0.020
Clostridium sensustricto 1	9	IBD	UC	0.79	0.66-0.97	0.009
Coprococcus 2	12	UC	IBD	1.32	1.08-1.62	0.006
Defluviitaleaceae UCG011	11	CD	\	1.25	1.03–1.50	0.023
Enterorhabdus	9	CD	IBD	0.82	0.68-0.98	0.032
Haemophilus	14	UC	\	1.17	1.01-1.36	0.033
Holdemanella	14	IBD	UC	0.87	0.77-0.97	0.014
Lachnospiraceae FCS020 group	17	IBD	UC	1.17	1.02-1.34	0.026
Lachnospiraceae ND3007 group	4	IBD	\	1.62	1.13-2.32	0.008
Lachnospiraceae UCG001	15	CD	\	0.81	0.67-0.97	0.023
Lachnospiraceae UCG010	13	IBD	CD	1.22	1.05-1.43	0.012
Odoribacter	9	CD	\	1.38	1.04-1.83	0.023
Oscillibacter	16	UC	IBD	0.84	0.72-0.97	0.018
Oxalobacter	12	IBD	UC, CD	1.17	1.07-1.29	0.001
Parasutterella	17	CD	\	1.22	1.03-1.45	0.023
Rikenellaceae RC9 gut group	15	CD	\	1.15	1.03-1.28	0.011
Ruminococcaceae UCG009	13	CD	\	0.81	0.69-0.96	0.014
Ruminococcaceae UCG014	17	IBD	CD	1.23	1.06-1.42	0.005
Ruminococcus 2	15	UC	\	0.81	0.67-0.99	0.039
Turicibacter	14	IBD	\	1.15	1.01-1.31	0.033

If microbiota is significant across different phenotypes, we only present the association with smallest P-values. CD, Crohn’s disease; CI, confidence interval; IBD, inflammatory bowel disease; IVW, inverse-variance weighted; OR, odds ratio; UC, ulcerative colitis.