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. 2022 Jul 4;15:896320. doi: 10.3389/fnmol.2022.896320

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Copyright © 2022 Borja, Zhang, Harwood, Jacques, Grooms, Chantre, Zhang, Barnett, Werley, Lu, Nagle, McManus and Dempsey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prestwick library pilot screen. Four 384-well plates from the Prestwick library were tested using Nav1.7 spiking HEK assay under 8 mM bath potassium. The mean spike amplitude of individual wells is shown in scatter plots for each individual plate. DMSO vehicle was used as the negative control and 1 μM TTX was used as the positive control. DMSO treated wells and TTX treated wells were used to calculate the Z′ factor. On each plate, a four-dose tetracaine titration series was also included to monitor assay variability across different plates.