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. 2022 Jul 4;15:896320. doi: 10.3389/fnmol.2022.896320

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Copyright © 2022 Borja, Zhang, Harwood, Jacques, Grooms, Chantre, Zhang, Barnett, Werley, Lu, Nagle, McManus and Dempsey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of hiPSC-derived cardiomyocyte counter-screening assay on Swarm instrument with pharmacological tool compounds and an identified screening hit. Representative BeRST1 voltage fluorescence traces are shown for 0.5 Hz paced cardiomyocytes treated with increasing concentrations of compound (yellow to dark blue). Cardiomyocytes were treated with (A) sodium channel blockers (Vixotrigine, PF-05089771, QS Compound 1) and (B) calcium channel and hERG channel blockers (Nifedipine, Dofetilide, E4031). Quantification of (A) action potential (AP) peak amplitude for sodium channel blockers and (B) AP70 width for calcium channel and hERG channel blockers are shown as mean ± SEM from triplicate wells. *p < 0.05 compared to DMSO control.