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. 2022 Jul 4;15:896320. doi: 10.3389/fnmol.2022.896320

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Copyright © 2022 Borja, Zhang, Harwood, Jacques, Grooms, Chantre, Zhang, Barnett, Werley, Lu, Nagle, McManus and Dempsey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simultaneous voltage and calcium imaging with the Swarm instrument on hiPSC-derived cardiomyocytes. (A) Representative fluorescence traces from hiPSC-derived cardiomyocytes expressing jRGECO1a reporter and loaded with BeRST1 voltage sensitive dye. Cardiomyocytes were paced with ten 0.5 Hz, 20 ms blue pulses. (B) Average fluorescence waveforms for voltage and Ca²⁺ in hiPSC-derived cardiomyocytes treated with increasing concentrations of calcium channel blocker Nifedipine (yellow to dark blue). (C) Quantification of voltage AP peak amplitude and integrated Ca²⁺ waveform area. Data shown as mean from triplicate wells with ±SEM as error bars. *p < 0.05 compared to DMSO control.