TABLE 1.

miRNAs secreted by adipose tissue and heart and targets potentially involved in bidirectional crosstalk.

Adipose tissue-enriched miRNAs with cardiovascular functions
miR	Target	Model	References
miR-325 miR-743b	UCP-1 TRPV4	Mice	Thomou et al. (2017)
		Rat	Feng et al. (2014)
		cells	Cheng et al. (2017)
			Zhou et al. (2021)
miR-98	PGC1α TGFβR1	Mice cells	Cheng et al. (2017)
			Song, et al. (2017)
			Neiburga et al. (2021)
			Sun et al. (2017)
miR-142-3p	LIFR VEGFA	Humans	Lörchner et al. (2021)
miR-140-5p
miR-222
miR-221
miR-15a			Ortega et al. (2013)
miR-520c-3p
miR-423-5p
miR-130b
miR-200a	TSC1	Cells	Fang et al. (2016)
miR-130b-3p	AMPLα1/α2BIRC6 UCP3	Mice	Gan et al. (2013)
Epicardial and Pericardial Adipose Tissue miRNAS
miR	Target	Model	References
miR-133a		Human explants	Shaihov-Teper et al. (2021)
miR-133b
miR 29a
miR-34a-3p	PNUTSKLF4 SEM4b BCL6 ALD2	Humans mice	Mari-Alexandre et al. (2019) Bernardo et al. (2012) Boon et al. (2013) Li et al. (2015) Qipshidze Kelm et al. (2018)
miR-34a-5p
miR-124-3p
miR-125a-5p
miR-658-5p
miR-1303
miR-4286
miR-99a	AKT-1	rat cells	Ramasamy et al., 2015, 2018
miR-99b
miR-100
Cardoac-enriched miRNAs
miR	Target	Model	References
miR-208a	PURβ	Mice	Van Rooij et al. (2007)
miR-208b	SOX-6		Van Rooij et al. (2009)
miR-499	MED13		Grueter et al. (2012)
miR-1	PRCM16	cells	Yin et al. (2013)
miR-133
miR-378	MAPK1	Cells	Fisher et al. (2011)
	IGF1
	GRB2
	KRS1
miR-21	PTEN	Cells	Cheng and Zhang, (2010a)
	PDCD4
	SPRY2
miR-30	RUNX2	Cells	Zaragosi et al. (2011)
	RIP140		Hu et al. (2015)