Table 3.
NLRP3 and cytokines concentrations in the serum of patients for Group 1, the patients who received the combination Midazolam+Fentanyl
|
Parameter |
Midazolam+Fentanyl Group 1 (n=10) |
||||
|
Before MIS |
After MIS |
p-value |
|||
|
Mean ± SD |
95% CI |
Mean ± SD |
95% CI |
||
|
NLRP3 [ng/mL] |
13.74±2.35 |
12.06–15.42 |
16.93±3.17 |
14.66–19.19 |
0.049* |
|
TNF-α [pg/mL] |
15.77±4.12 |
12.82–18.71 |
19.54±3.54 |
17.10–22.07 |
0.044* |
|
IL-6 [pg/mL] |
11.63±3.75 |
8.95–14.31 |
13.13±3.72 |
10.46–15.79 |
0.436 |
|
IL-10 [pg/mL] |
18.12±3.12 |
15.89–20.35 |
21.78±3.50 |
19.28–24.29 |
0.035* |
CI: Confidence interval; IL: Interleukin; MIS: Minimally invasive surgery; NLRP3: Nucleotide-binding domain (NOD) and leucine-rich repeat protein 3; SD: Standard deviation; TNF-α: Tumor necrosis factor-alpha. *Statistically significant