Table 3.

Studies Evaluating Primary Tube Shunt Surgery and Trabeculectomy with MMC

Author	Procedure	Number of Eyes	Success Rate	IOP Success Criteria (mm Hg)	Mean Follow-up (months)
Martini et al7	Trabeculectomy with MMC	30	96.6% at 1 year	≤ 18	12.0
Scott et al8	Trabeculectomy with MMC	89	77.9% at 2 years	≤ 21 and ≥ 30% reduction	18.4
Rasheed9	Trabeculectomy with MMC	25	92% at last follow-up	< 20	17.8
			72% at last follow-up	< 15
			60% at last follow-up	< 12
Singh et al10	Trabeculectomy with MMC	54	98.1% at 1 year	< 18	11.1
			96.3% at 1 year	< 21
			83.3% at 1 year	< 15
			57.4% at 1 year	< 12
Bindlish et al11	Trabeculectomy with MMC	123	57.7% at 5 years	< target and > 6	NR
Beckers et al12	Trabeculectomy with MMC	60	60% at 5 years	≤ 15	NR
Fontana et al13	Trabeculectomy with MMC	292	62% at 3 years	≤ 18 and ≥ 20% reduction	NR
			56% at 3 years	≤ 15 and ≥ 25% reduction
			46% at 3 years	≤ 12 and ≥ 30% reduction
Shigeeda et al14	Trabeculectomy with MMC	123	74.1% at 8 years	< 21 and ≥ 30% reduction	81.6
			67.0% at 8 years	< 18
			44.5% at 8 years	< 16
Kim et al15	Trabeculectomy with MMC	30	73.3% at last follow-up	< 21	78.0
			40.0% at last follow-up	< 18
			26.7% at last follow-up	< 15
			26.7% at last follow-up	< 12
Reibaldi et al16	Trabeculectomy with MMC	67	73.1% at last follow-up	≤ 18	127
			64.2% at last follow-up	≤ 16
			56.7% at last follow-up	≤ 14
Alwitry et al17	Trabeculectomy with MMC	59	93.2% at 1 year	≤ 21	19.3
			88.2% at 1 year	≤ 18
			83.1% at 1 year	≤ 16
Palanca-Capistrano et al18	Trabeculectomy with MMC	58	66% at 5 years	≤ 21 and ≥ 20% reduction and ≥ 6	45.3
Takihara et al19	Trabeculectomy with MMC	175	92.6% at 3 years	< 21	37.5
			81.3% at 3 years	< 18
			54.2% at 3 years	< 15
Cillino et al20	Trabeculectomy with MMC	20	85% at 5 years	≤ 21	NR
			70% at 5 years	≤ 17
			40% at 5 years	≤ 15
Wilson et al	Trabeculectomy with MMC*	64	68.1% at 41–52 months	< 21 and ≥ 15% reduction and > 5	31
	Ahmed implant	59	69.8% at 41–52 months		31
Panarelli et al	Trabeculectomy with MMC	70	76% at 3 years	≤ 21 and ≥ 20% reduction and > 5	33
	Baerveldt implant	55	87% at 3 years		27
Molteno et al23	Trabeculectomy†	718‡	82% at 10 years	≤ 21	92
	SP/DP Molteno implant, Molteno3 implant	260‡	96% at 10 years		60
Valimaki and Ylilehto24	Molteno3 implant	106‡	91% at 3 years	≤ 21 and ≥ 20% reduction and > 5	35
Namavari et al25	Baerveldt implant	37	84% at last follow-up	≤ 21 and ≥ 20% reduction and > 5	NR

DP = double-plate; IOP = intraocular pressure; MMC = mitomycin C; NR = not reported; SP = single-plate

^*6 eyes did not receive MMC

^†An intraoperative antifibrotic agent was used in 15 (2%) patients

^‡Some patients were pseudophakic at baseline