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. 2022 Jun 30;65(13):8998–9010. doi: 10.1021/acs.jmedchem.2c00205

Figure 3.

Figure 3

Anti-prion effect of anti-SERPINA3 hit compounds in ScGT1 RML cell lines. (A,C) Representative Western blot image of PrPSc, total PrP, and β-actin in lysates from ScGT1 RML treated with vehicle (CTRL) or compounds G and H at 40 μM, or compound 5 (ARN1468) at 20 μM. Molecular weight markers are represented on the right (kDa). (B,D) Densitometric analysis of normalized PrPSc levels in ScGT1 RML treated with the vehicle or the drug. Experiments have been performed in triples (n = 6). Statistical significance was assessed using Friedman test and Dunn’s multiple comparison compared to control cells (B) or Wilcoxon matched-pair signed rank test (D) *p < 0.05.