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. 2022 Jun 30;65(13):8998–9010. doi: 10.1021/acs.jmedchem.2c00205

Figure 4.

Figure 4

Anti-prion effect of compound 5 in ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines. (A–C) Representative Western blot images of PrPSc, total PrP, and β-actin in lysates from ScGT1 22L (A), ScN2a RML (B), and ScN2a 22L (C) treated with vehicle (CTRL) or compound 5 at 20 μM. Molecular weight markers are shown on the right (kDa). (D–F) Densitometric analysis of normalized PrPSc levels in ScGT1 22L (D), ScN2a RML (E), and ScN2a 22L (F) treated with the vehicle or the drug. Experiments have been performed in six times (n = 6). Statistical significance was assessed by Wilcoxon matched pairs signed rank test, *p < 0.05.