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. 2022 Jun 27;65(13):9050–9062. doi: 10.1021/acs.jmedchem.2c00270

Figure 1.

Figure 1

Inhibition of clinical CF isolates of P. aeruginosa biofilm formation in the presence of AMPs. P. aeruginosa bacteria were incubated for 24 h in the presence of AMPs. Biofilm after treatment was examined using 0.1% CV staining followed by absorbance measurements at 590 nm. The results are reported relative to untreated biofilm. Background measurements with no added bacteria were performed as blanks. (A–D) Biofilms were inhibited using 1.56 μM (A) LL-37, (B) Seg5D, (C) Seg6D, and (D) Amp1D. (E) Median of the biofilm biomass under 0.78 and 1.56 μM treatments. (F) Median of the biofilm biomass in MIC dilutions. Statistical significance determined by ANOVA. Correlation was tested by Pearson’s R.