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. 2022 Jun 27;65(13):9050–9062. doi: 10.1021/acs.jmedchem.2c00270

Figure 6.

Figure 6

AMP inhibition and degradation activity against clinical CF isolate P. aeruginosa biofilms in the presence of CF sputum. A 1:10 BM2:CF sputum ratio was used for inhibition and degradation measurements. Surface-associated biofilm after treatment was examined using 0.1% CV staining followed by absorbance measurements at 590 nm. Results are reported relative to untreated biofilm. Background measurements with no added bacteria were performed as blanks. (A) Biofilm inhibition by AMPs using with the highest MIC for each isolate. (B) Biofilm degradation by AMPs in the treatment range of 50–1.56 μM. The statistical significance from untreated biofilm was determined by ANOVA.