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. 2022 Jul 13;20(3):15593258221113791. doi: 10.1177/15593258221113791

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Apigenin protects against deadly intestinal injury caused by irradiation. (A-B) Survival curves of vehicle or API-treated C57BL/6J mice after 10 Gy TBI and relative body weight at 5 d. (C-D) Survival curves of mice treated with vehicle or API after 12 Gy TAI and relative body weight at 5 d (n = 10). (E-F) Representative images of H&E-stained intestinal sections 3.5 days after 8, 10, 12 and 14 Gy TBI and quantitative analysis of surviving crypt (n = 4). Values are mean ± SEM; Scale bar = 200 μm; *P < .05, **P < .01, ****P < .0001, vehicle vs apigenin treatment by unpaired two-tailed Student’s t-test. TAI, total abdominal irradiation; TBI, total body irradiation.