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. 2022 Jul 13;20(3):15593258221113791. doi: 10.1177/15593258221113791

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© The Author(s) 2022

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Figure 3. — Apigenin enhances crypt regeneration after irradiation. (A-B) Representative images of H&E-stained intestinal sections 3.5 d after 10 Gy TBI and quantitative analysis of crypt depth. (C-D) Representative images of BrdU IHC intestinal sections at 3.5 d after 10 Gy TBI and quantitative analysis of regenerated crypts per circumference. Scale bar = 100 μm. (E-F) Representative images of BrdU IHC intestinal sections at the indicated times after 10 Gy TBI and quantitative analysis of BrdU+ cells in each crypt. Scale bar = 50 μm. Values are mean ± SEM; n = 4 mice per group. ****P < .0001, vehicle treated with apigenin by unpaired two-tailed Student’s t-test. BrdU,5-Bromo-2′-deoxyuridine; IHC, immunohistochemistry.