TABLE 3.

Comparison of studies evaluating short chain fatty acids (SCFA) effects on murine amyloid models.

Study	Treatment	Mouse model	Microbiome	Mouse age during treatment	Effect on amyloid burden
Fernando et al., 2020	NaB was added to chow pellets at a concentration of either 40 mg/kg or 120 mg/kg where mice would receive either 5 mg/kg/day, or 15 mg/kg/day	5xFAD with APOE3	Conventional	From 8 weeks to 20 weeks	Reduced
Jiang et al., 2021	0.2 g/kg daily intraperitoneal injection of NaB (0.1 ml/10 g) *	5xFAD	SPF	From 8 weeks to 10 weeks	Reduced
Colombo et al., 2021	67.5 mM sodium acetate, 25 mM sodium propionate, 40 mM sodium butyrate, pH 6.8 in drinking water	APPPS1	SPF	From 8 weeks to 13 weeks	Increased
Zajac et al., 2022	67.5 mM sodium acetate, 25 mM sodium propionate, 40 mM sodium butyrate, pH 6.8 in drinking water *	APP/PS1	Conventional	From 20 weeks to 40 weeks	No change

*SCFA treatment was compared to saline control.