Table 1.

Baseline Characteristics of Older Adults with Dementia and OAB across Non-users and Users of Antimuscarinic Medications

Characteristics		AntimuscarinicNon-Users (n = 1,89,257; 89.65%)	Antimuscarinic Users (n = 21,848; 10.35%)	Standardized Difference of Proportions (D)	P-value
Predisposing Characteristics
Age (in years)	≥ 65–75 years	42,880 (22.66)	6,287 (28.78)	0.21	<.0001*
	≥ 75–85 years	80,333 (42.45)	9,900 (45.31)
	≥ 85 years	66,044 (34.90)	5,661 (25.91)
Gender	Male	67,205 (35.51)	7,080 (32.41)	0.07	<.0001*
	Female	1,22,052 (64.49)	14,768 (67.59)
Race	White	1,58,334 (83.66)	18,753 (85.83)	0.09	<.0001*
	Black	17,605 (9.30)	1,498 (6.86)
	Other	13,318 (7.04)	1,597 (7.31)
Need Characteristics
Abnormal Involuntary Movements		7,956 (4.20)	1,264 (5.79)	0.07	<.0001*
Anxiety		50,753 (26.82)	6,765 (30.96)	0.09	<.0001*
Bipolar Disease		8,090 (4.27)	1,217 (5.57)	0.06	<.0001*
Drug Induced Acute Dystonia		54 (0.03)	6 (0.03)	−0.00	0.93
Gastro-esophageal Reflux Syndrome		61,427 (32.46)	8,218 (37.61)	0.11	<.0001*
Insomnia		24,018 (12.69)	3,691 (16.89)	0.12	<.0001*
Irritable Bowel Syndrome		5,083 (2.69)	841 (3.85)	0.07	<.0001*
Muscle Spasms/ Low Back Pain		39,747 (21.00)	6,606 (30.24)	0.21	<.0001*
Neuropathic Pain		3,001 (1.59)	598 (2.74)	0.08	<.0001*
Schizophrenia		6,534 (3.45)	745 (3.41)	−0.00	0.74
Secondary Parkinsonism		2,529 (1.34)	357 (1.63)	0.02	0.00*
Benign Prostatic Hyperplasia		32,793 (48.80ⱡ)	4,570 (64.55ⱡ)	0.09	<.0001*
Chronic Constipation		44,670 (23.60)	5,640 (25.81)	0.05	<.0001*
Epilepsy		12,327 (6.51)	1,316 (6.02)	−0.02	0.01*
Delirium		41,068 (21.70)	4,519 (20.68)	−0.02	0.00*
Falls/Fractures		85,255 (45.05)	10,872 (49.76)	0.09	<.0001*
Myasthenia Gravis		374 (0.20)	67 (0.31)	0.02	0.00*
Narrow-angle Glaucoma		29,519 (15.60)	3,593 (16.45)	0.02	0.00*
Parkinson’s Disease		17,392 (9.19)	2,406 (11.01)	0.06	<.0001*
Myocardial Infarction		7,662 (4.05)	910 (4.17)	0.01	0.41
Syncope		25,479 (13.46)	3,340 (15.29)	0.05	<.0001*
Urinary Tract Infection		92,139 (48.68)	12,306 (56.33)	0.15	<.0001*
Skin Infection		15,492 (8.19)	1,822 (8.34)	0.01	0.43
Vulvovaginitis		3,924 (2.07)	780 (3.57)	0.09	<.0001*
Baseline Anticholinergic Load		61,930 (32.72)	7,736 (35.41)	0.06	<.0001*
Elixhauser’s Score (Mean, SD)		11.79 (10.69)	11.66 (10.60)	−0.01	0.09

SD Standard Deviation,

^*Statistical significance at p-value < 0.05,

^ⱡDenominator is male population within non-users and users