Table 1. Formulations for Preparing AE Extract-Loaded SLNs and Particle Characteristicsa.
| parameters |
particle
characteristics |
||||||
|---|---|---|---|---|---|---|---|
| formula | Compritol ATO 888 (g) | Tween 80 (%) | Span 80 (%) | PS (nm) ± SD | PDI ± SD | ZP (mV) ± SD | entrapment efficiency (%) ± SD |
| F1 | 10.00 | 1.00 | 0.00 | 1240.05 ± 365.44 | 0.564 ± 0.08 | –23.10 ± 4.55 | 4.21 ± 2.01 |
| F2 | 10.00 | 0.50 | 0.00 | 3546.77 ± 548.78 | 0.321 ± 0.01 | –19.75 ± 3.78 | 40.84 ± 1.42 |
| F3 | 1.50 | 0.50 | 0.25 | 2692.93 ± 218.86 | 0.293 ± 0.04 | –31.42 ± 2.06 | 13.51 ± 0.27 |
| F4 | 1.50 | 0.50 | 0.50 | 2606.76 ± 125.83 | 0.248 ± 0.03 | –31.09 ± 0.61 | 18.24 ± 1.07 |
| F5 | 1.50 | 0.50 | 1.00 | 2056.5 ± 407.20 | 0.393 ± 0.07 | –33.07 ± 3.33 | 15.87 ± 2.22 |
| F6 | 1.50 | 0.50 | 2.00 | 1372.3 ± 100.36 | 0.120 ± 0.05 | –37.48 ± 0.90 | 21.73 ± 1.79 |
| F7 | 1.50 | 0.50 | 3.00 | 628.06 ± 159.36 | 0.210 ± 0.04 | –37.65 ± 0.90 | 31.28 ± 0.98 |
| F8 | 1.50 | 0.50 | 4.00 | 1450.96 ± 66.10 | 0.324 ± 0.08 | –39.77 ± 0.86 | 24.99 ± 0.44 |
| F9 | 1.50 | 0.50 | 5.00 | 1129.16 ± 61.88 | 0.355 ± 0.02 | –44.46 ± 1.12 | 25.37 ± 0.56 |
a
PS = particle size, PDI = polydispersity index, ZP = zeta potential, SD = standard deviation.