Table 1. Control Compound Affinities/Kinetic Parameters Binding to Adenosine Receptors A₁, A_2A, A_2B, and A₃^a.

receptor	compound	ka (M–1 s–1)	kd (s–1)	KD	Ki (literature)	figure
A2A	adenosine	9.53(±0.05) × 105	0.016(±0.008)	17.3(±0.1) nM	150 nM	1A
A2A	ZM 241385	2.42(±0.08) × 106	6.92(±0.03) × 10–4	286(±1) pM	395 pM
A2A	theophylline	N/A	N/A	3.63(±0.05) μM	N/A	1B
A2A	allopurinol	N/A	N/A	77(±3) μM	N/A
A2A	caffeine	N/A	N/A	5.51(±0.08) μM	N/A
A1	SLV320	6.27(±0.01) × 105	0.0034(±0.0004)	5.46(±0.01) nM	1 nM	2C–F
A2A	CV1808	2.93(±0.03) × 106	0.027(±0.002)	9.1(±0.1) nM	76 nM
A2B	LUF5834	1.10(±0.06) × 105	0.0086(±0.0004)	78.2(±0.03) nM	12 nM
A3	adenosine	2.49(±0.03) × 104	0.077(±0.007)	3.07(±0.01) μM	290 nM

^ak_a, on-rate; k_d, off-rate; K_D, affinity; K_i, inhibition constant from literature.