Table 5. Pharmacokinetic Properties of Compound 12h in Male Rats.
| parameter | IV (5 mg/kg)a | PO (10 mg/kg)a |
|---|---|---|
| Tmax (h) | NA | 6.67 ± 2.31 |
| Cmax (μg/mL) | NA | 1.19 ± 0.35 |
| T1/2 (h) | 6.59 ± 3.86 | 8.5 ± 3.57 |
| AUC0–8h (μg·h/mL) | 26.8 ± 20.01 | 13.64 ± 2.93 |
| AUC∞ (μg·h/mL) | 30.63 ± 25.88 | 17.2 ± 3.52 |
| CL (L/kg/h) | 0.27 ± 0.21 | NA |
| VSS (L/kg) | 1.83 ± 1.15 | NA |
| F (%) | NA | 25.45 |
Data are expressed as mean ± SD (n = 3).