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. 2022 Jun 21;13(7):1052–1061. doi: 10.1021/acsmedchemlett.2c00070

Table 5. Pharmacokinetic Properties of Compound 12h in Male Rats.

parameter IV (5 mg/kg)a PO (10 mg/kg)a
Tmax (h) NA 6.67 ± 2.31
Cmax (μg/mL) NA 1.19 ± 0.35
T1/2 (h) 6.59 ± 3.86 8.5 ± 3.57
AUC0–8h (μg·h/mL) 26.8 ± 20.01 13.64 ± 2.93
AUC (μg·h/mL) 30.63 ± 25.88 17.2 ± 3.52
CL (L/kg/h) 0.27 ± 0.21 NA
VSS (L/kg) 1.83 ± 1.15 NA
F (%) NA 25.45
a

Data are expressed as mean ± SD (n = 3).