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. 2022 Jul 5;13(7):1165–1171. doi: 10.1021/acsmedchemlett.2c00219

Table 1. BRD4 and c-Myc Inhibition, MM Proliferation, and Metabolic and Caco-2 Data for Various Substituted Carbolines.

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a

Number of determinations in parentheses.

b

Human = h, rat = r, mouse = ms, dog = d, monkey = mk.

c

Measurement limit = 120 min.

d

Efflux ratio = (A–B)/(B–A).

e

Percent remaining after 10 min incubation.17