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. 2022 Jul 5;13(7):1165–1171. doi: 10.1021/acsmedchemlett.2c00219

Table 2. Comparison of BMS-986158 and 15 Preclinical PK Parameters17.

  mouse
 rat
 dog
 monkey
  BMS-986158 15 BMS-986158 15 BMS-986158 15 BMS-986158 15
dose (iv/po, mg/kg) 1.75/5.0 1.0/3.0 1.0/5.0 1.0/5.0 0.1/0.3 0.1/0.3 0.1/0.3 0.1/0.3
CLp ((mL/min)/kg) 12 4.2 41 18 15 13 32 4.3
Vd (L/kg) 1.9 1.4 4.3 2.9 5.3 5.8 4.2 1.3
half-life (iv, h) 1.9 3.4 4.2 4.1 5.6 7.6 2.0 4.0
F (%) 100 100 47 74 59 73 16 85
AUC (po, nM·h) 18000 25000 2000 6600 410 550 85 1900