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. 2022 Jun 20;13(7):1182–1190. doi: 10.1021/acsmedchemlett.2c00124

Scheme 1. (A) PROTAC Structure and Typical Synthesis, Including Time-Intensive Chromatographic Purification, and (B) Overview of the Direct-to-Biology (D2B) Strategy, Which Streamlines Plate-Based Synthesis and Evaluation of Unchromatographed PROTACs.

Scheme 1