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. 2022 Jul 18;22:351. doi: 10.1186/s12870-022-03723-5

Fig. 2.

Fig. 2

Functionally characterized miRNAs associated with the immune response against bacterial, fungal, and viral pathogens, as well as insect herbivores. Pathogen-derived effector molecules elicit the expression of MIR genes by RNA polymerase II via mitogen-activated protein (MAP) kinase signaling. The long hairpin transcript is processed by Dicer-like protein (DCL). The miR162 targets the DCL and produces ROS. Various miRNAs such as miR162, miR164, miR169, miR398, and miR439 also participate in the immune response mechanism via ROS. On the other hand, a tug of war between AGO1 and AGO18 for binding to miR528 and miR168 facilitates the expression of strong resistance against the invading viral pathogen through the production of reactive oxygen species (ROS). The miR156, miR396, and miR159 confer resistance to pathogens and insect pests by targeting transcription factors through a mechanism modulated by phytohormones