Fig. 6.

Integrin αVβ3 mediated the activation of FAK/P38 signaling pathway induced by WJ-MSCs ECM in HUVECs. a–e Transwell for HUVECs migration assay and quantitative analysis of migrated HUVECs numbers. Bar = 50 μm. Mean ± S.E.M., n = 3. f–j Immunofluorescently stained for VEGF of HUVECs (magnification: × 200). Mean ± S.E.M., n = 3. HY-100563: Integrin αVβ3 specific antagonist. k–m Protein expressions of FAK, p-FAK, P38 and p-P38 in HUVECs were determined by western blotting. Mean ± S.E.M. n = 3. The P value was calculated using one-way ANOVA and independent samples t-test. *P < 0.05, **P < 0.01 versus control