Table 3.
Agreement Calculation of Measured Vascular Features Between AutoMorph and Expert Annotation
| ICC (95% Confidence Interval) | |||
|---|---|---|---|
| Zone B | Zone C | Whole Image | |
| DR HAGIS | |||
| Fractal dimension | 0.94 (0.88–0.97) | 0.98 (0.95–0.99) | 0.94 (0.88–0.97) |
| Vessel density | 0.98 (0.96–0.99) | 0.97 (0.94–0.99) | 0.94 (0.88–0.97) |
| Average width | 0.95 (0.89–0.98) | 0.96 (0.93–0.98) | 0.97 (0.95–0.99) |
| Distance tortuosity | 0.80 (0.59–0.91) | 0.85 (0.69–0.93) | 0.86 (0.73–0.93) |
| Squared curvature tortuosity | 0.68 (0.34–0.85) | 0.88 (0.75–0.94) | 0.84 (0.68–0.92) |
| Tortuosity density | 0.89 (0.77–0.95) | 0.70 (0.38–0.86) | 0.87 (0.74–0.93) |
| IOSTAR-AV | |||
| CRAE (Hubbard) | 0.81 (0.56–0.92) | 0.82 (0.57–0.91) | — |
| CRVE (Hubbard) | 0.8 (0.54–0.91) | 0.78 (0.52–0.89) | — |
| AVR (Hubbard) | 0.87 (0.69–0.94) | 0.81 (0.66–0.92) | — |
| CRAE (Knudtson) | 0.76 (0.45–0.9) | 0.75 (0.44–0.89) | — |
| CRVE (Knudtson) | 0.85 (0.67–0.94) | 0.86 (0.58–0.9) | — |
| AVR (Knudtson) | 0.85 (0.66–0.94) | 0.82 (0.51–0.91) | — |
The agreement of vessel caliber was validated on the IOSTAR-AV dataset, other metrics with the DR HAGIS dataset. Because caliber features rely on the six largest arteries and veins in Zones B and C, there is no caliber feature for the whole image level.