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. 2022 Jul 18;288:121671. doi: 10.1016/j.biomaterials.2022.121671

Fig. 3.

Fig. 3

Neutralization of SARS-CoV-2 Delta and Omicron variants in NP swab samples by CTB-ACE2 gum (A) Images from clinical NP/OP swab samples of Patients #614, #615 treated with CTB-ACE2 gum (0.46 or 0.92 μg CTB-ACE2 protein in 25 and 50 mg of gum respectively) (B) Quantitation of microbubbles show a significant difference between the untreated Omicron strain vs CTB-ACE2 gum at both concentrations. (***p-value = 0.0001). All images shown share the same scale bar. (C) Images from clinical NP/OP swab samples of Patients #151, #153 and #155 treated with ACE2 gum (0.46 or 0.92 μg CTB-ACE2 protein in 25 and 50 mg of gum respectively). (D) Quantitation of microbubbles show a significant difference between the untreated Delta strain vs CTB-ACE2 gum at both concentrations. (***p-value = 0.0009). All data shown were analyzed by One-way ANOVA test. Omicron and Delta SARS-CoV-2 strain identification is based on whole genome sequencing or S gene target failure or date of collection. Please refer to Table 1 for other details on patient IDs.