Table 2.
Diagnostic accuracy of Readers 1 and 2 when using the morphologic and comparative approach, respectively, and according to the germline genetic status of the patients. SN = Sensitivity; SP = Specificity; AUC = Area Under the Curve (in ROC analysis). MC1R alleles: R = variant strongly associated with the red hair colour phenotype or RHC; r = variant low-associated with RHC; - = wild-type.
| MORPHOLOGY | COMPARISON | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GOLD STANDARD | READER 1 | READER 2 | READER 1 | READER 2 | |||||||||||
| Melanoma | Nevi | SN | SP | AUC | SN | SP | AUC | SN | SP | AUC | SN | SP | AUC | ||
| ALL lesions | 26 | 389 | 76.9% | 84.3% | 0.806 | 76.9% | 90.2% | 0.826 | 69.2% | 95.9% | 0.836 | 73.1% | 95.1% | 0.841 | |
| CDKN2A status | MC1R genotype | Melanoma | Nevi | SN | SP | AUC | SN | SP | AUC | SN | SP | AUC | SN | SP | AUC |
| Mutated | ALL | 11 | 173 | 81.8% | 80.9% | 0.814 | 72.7% | 90.2% | 0.815 | 72.7% | 96.5% | 0.846 | 72.7% | 94.8% | 0.838 |
| Wild-type | ALL | 15 | 216 | 73.3% | 87.0% | 0.802 | 80.0% | 90.3% | 0.851 | 66.7% | 95.4% | 0.810 | 73.3% | 95.4% | 0.844 |
| ALL | RR, Rr,R- | 14 | 225 | 78.6% | 84.0% | 0.813 | 64.4% | 89.8% | 0.770 | 64.3% | 96.9% | 0.806 | 57.1% | 95.1% | 0.761 |
| ALL | rr, r-,-- | 12 | 164 | 75.0% | 84.8% | 0.799 | 91.7% | 90.9% | 0.913 | 75.0% | 94.5% | 0.848 | 91.7% | 95.1% | 0.934 |
| Mutated | RR, Rr,R- | 7 | 104 | 71.4% | 77.9% | 0.747 | 57.1% | 87.5% | 0.723 | 57.1% | 97.1% | 0.771 | 57.1% | 94.2% | 0.757 |
| Mutated | rr, r-,-- | 4 | 69 | 100% | 85.5% | 0.928 | 100% | 94.2% | 0.971 | 100% | 95.7% | 0.978 | 100% | 95.7% | 0.978 |
| Wild-type | RR, Rr,R- | 7 | 121 | 85.7% | 89.3% | 0.875 | 71.4% | 91.7% | 0.816 | 71.4% | 96.7% | 0.841 | 57.1% | 95.9% | 0.765 |
| Wild-type | rr, r-,-- | 8 | 95 | 62.5% | 84.2% | 0.734 | 87.5% | 88.4% | 0.880 | 62.5% | 93.7% | 0.781 | 87.5% | 94.7% | 0.911 |