TABLE 2.

Results of SNP18 in all ethnicities and SNP143 in women excluded from the White European group compared to White European in prospective PROCAS without breast cancer and breast cancers in White British

	Total number	Mean PRS no cancer except White British	Mean log PRS (95% CI)	P value c
Group SNP18
White British no cancer	8039	1.00	−0.053 (−0.060, −0.046)	Ref.
White British cancer	584	1.10	0.049 (0.024, 0.075)	<.001
Asian b	119	1.06	0.012 (−0.044, 0.067)	.029
Black b	112	1.22	0.150 (0.090, 0.211)	<.001
Unknown b	274	1.03	−0.031 (−0.073, 0.011)	.288
Jewish b	120	1.14	0.078 (0.018, 0.139)	<.001
Mixed b	44	1.16	0.084 (−0.030, 0.199)	.005
White other b	159	1.05	−0.010 (−0.065, 0.045)	.117
Combined groups SNP18
Presumed White European no cancer	8436	1.00	−0.051 (−0.058, −0.044)	Ref.
Presumed White European cancer	621 a	1.11 a	0.056 (0.031, 0.081)	<.001
BAME group: Jewish, Black, Asian, mixed
No cancer	395	1.14	0.079 (0.046, 0.112)	<.001 (ref. White no cancer)
BAME group cancer	37	1.15	0.086 (−0.022, 0.195)	.902 (ref. BAME no cancer)
Jewish	120	1.14	0.078 (0.018, 0.139)	<.001 (ref. White no cancer)
Jewish cancer	15	1.06	−0.011 (−0.227, 0.204)	–
Group SNP143
Presumed White European no cancer	1784	0.98	−0.150 (−0.174, −0.127)	Ref.
Presumed White European cancer	621	1.27	0.116 (0.077, 0.155)	<.001
BAME group no cancer	84	1.40	0.201 (0.087, 0.315)	<.001 (ref. White no cancer)
BAME group cancer	30	1.31	0.134 (−0.055, 0.323)	.551 (ref. BAME no cancer)
Jewish no cancer	31	1.26	0.092 (−0.107,0.291)	<.001
Jewish cancer	12	1.30	0.049 (−0.356,0.453)	–
Black no cancer	18	1.91	0.504 (0.234, 0.774)	<.001
Asian no cancer	26	1.29	0.167 (−0.018, 0.351)	.002
Mixed no cancer	8	1.15	0.065 (−0.281, 0.412)	.202

^a Mean SNP18 PRS for 525 White European women diagnosed with breast cancer before entry was identical at 1.11 to the 621 diagnosed after entry.

^b Number of cancers too small to provide separately and not included in numbers.

^c P value given for comparison with reference category.