TABLE 2.

Liver function tests before and after statin treatment in interventional studies (Panel A) and in patients taking or not taking statins in cross‐sectional studies (Panel B)

Year/Author	ALT before statin	ALT after statin	AST before statin	AST after statin	GGT before statin	GGT after statin
Panel A. Interventional studies
2003 Kiyici 26	81.8	44.8	45.4	32.1	64.2	37.2
2004 Hatzitolios 27	115.0	76.6	68.0	46.0	98.0	33.0
2006 Antonopoulos 28	90.9	28.30	38.0	30.4	52.0	39.7
2006 Athyros 29	54.0	32.0	38.0	25.0	52.0	33.0
2008 Hyogo 30	89.4	35.9	51.1	25.8	87.0	51.0
2009 Abel 31	66.6	29.5	51.1	25.8	87.0	51.0
2010 Kimura 32	61.8	56.2	48.9	33.1	90.3	65.0
2010 GREACE 33	57.0	37.0	49.0	26.0	70.0	38.0
2011 Hyogo 34	102.1	68.2	62.6	41.8	94.5	59.6
2011 Maroni 35	37.6	44.7	26.3	34.3	59.0	86.5
2012 Han‐1 36	58.7	53.3	44.5	41.5	79.9	68.8
2012 Han‐2 36	56.4	51.3	39.5	39.0	75.7	64.8
2012 Hyogo 37	89.0	56.6	48.0	33.0	90.4	65.1
2012 Nakahara 38	68.7	50.3	40.1	33.8	78.7	61.4
2015 Derosa‐1 39	58.0	36.0	36.0	38.0	‐	‐
2015 Derosa‐2 39	55.0	38.0	58.0	39.0	‐	‐
2017 Bril 40	66.0	38.0	48.0	31.00	‐	‐
2017 Cioboatǎ 41	82.6	43.6	83.1	43.3	53.0	43.1
2018 Hadzi‐Petrushev 42	41.9	30.8	42.7	24.2	‐	‐

Panel B. Cross‐sectional studies
	ALT on statin	ALT not on statin	AST on statin	AST not on statin	GGT on statin	GGT not on statin
2006 Dallas Heart Study 43	30.0	25.0	‐	‐	‐	‐
2007 Ekstedt 44	61.0	63.0	35.0	36.0	‐	‐
2016 Nascimbeni 45	42.0	39.0	32.0	31.0	50.0	54.0
2017 Bril 40	75.0	57.0	53.0	43.0	‐	‐
2017 Del Ben 21	34.5	29.0	25.8	23.9	44.5	43.8
2020 Khoo 46	44.3	46.6	31.2	36.8	45.8	54.5

All values expressed as U/L.

ALT: alanine aminotransferase; AST: aspartate transaminase; GGT: gamma‐glutamyl transferase.