Figure 2 .

Shank3b ^−/− mice display reduced evading and exploratory behaviors following repetitive whisker stimulation in WN. (A) WN experimental design; four different parameters (freezing, guarded behavior, evasion, and climbing in response to stick presentation) were monitored across the sham session (no tactile stimulation) and three different experimental trials of repetitive whisker stimulation (see Materials and Methods for details). (B–D) Time spent in freezing (B), guarded behavior (C), and evading (D), expressed as % over the total time of observation in each session (sham and trials 1–3). (E) Number of climbing events in response to stick presentation, expressed as the total number of events during each session (sham and trials 1–3). All plots report mean values ± SEM. ^*P < 0.05, ^**P < 0.01, Komogorov–Smirnov test. Genotypes are as indicated (n = 19 Shank3b^+/+ and 18 Shank3b^−/−).