Table 6.

Summary of mutual prodrugs of 5‐FU for targeted drug delivery.

Compd.	Type of hybrid	Linker	Study	Outcomes	Ref.
22  c, 24 a–c	5‐FU/aspartic acid oligopeptides‐based	succinate	HAP binding study, drug release study, in vitro cytotoxicity assay, in vivo biodistribution in mice tissue	targeting the bone antiproliferative activity	[101a]
26 a–c	5‐FU/F16	carboxylic, amidic, disulfide	in vitro cytotoxicity assay, detection of cellular uptake, colocalization assay, detection of apoptosis and cell cycle, in vitro measurement of intracellular oxidation level, stability study in PBS or DMEM medium	targeting mitochondria ↑ antiproliferative activity	[107]
27, 28	5‐FU/c(RGDyK)	amide, disulfide	in vitro cytotoxicity assay, chemostability study, 5‐FUA release assay	integrin targeted chemotherapy ↑ antiproliferative activity	[115]