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. 2021 Jul 1;30(23):6072–6086. doi: 10.1111/mec.16020

FIGURE 3.

FIGURE 3

The core MHC region in humans (Chromosome 6) holds six MHC‐I genes in open reading frame (HLA‐A to ‐C and HLA‐E to ‐G), and the core MHC region in cynomolgus macaque Macaca fascicularis (Chromosome 4) holds five orthologous MHC‐I loci (note: no MHC‐C locus). A subset (400 kb in human and 500 kb in cynomolgus macaque) of these homologous genomic MHC regions is shown here, the flanking genes POU5F1 and MIC genes (green boxes), and the MHC‐I genes (orange and yellow boxes) being indicated. (a) MHC class I region in human (HLA) with single HLA‐C and HLA‐B gene copies (locations from ensembl GRCh38.p13 assembly chromosome 6) and (b) MHC class I region in cynomolgus macaque with tandemly duplicated MHC‐B gene copies (Mafa, MHC‐B genes (Watanabe et al., 2007), POU5F1 and MIC locations from ensembl Macaca_fascicularis_5.0 assembly chromosome 4). Note: MHC class I gene(s) at the B locus is called HLA‐B in humans and Mafa‐B in cynomolgus macaque