TABLE 2.
FVIII utilisation during the PROTECT VIII extension study
| FVIII utilisation | On‐ demand (n = 14) | Prophylaxis | ||||
|---|---|---|---|---|---|---|
| Twice weekly n = 23 |
Every 5 days n = 33 |
Every 7 days n = 23 |
Variable frequency a n = 28 |
Total Prophylaxis (n = 107) | ||
| Total dose per year, IU/kg, median (range) | 1394.2 (736.5–3998.2) | 3916.9 (2776.8–5424.3) | 3503.5 (2995.2–4702.9) | 3129.7 (2623.5–5232.8) | 3826.2 (2789.6 (5328.0) | 3539.1 (2623.5–5424.3) |
| Total dose per infusion, IU/kg, median (range) | 32.8 (22.2–60.9) | 36.7 (26.8–42.8) | 44.8 (40.7–59.6) | 59.0 (51.2–107.5) | 50.68 (29.1–63.8) | 46.9 (26.8–107.5) |
| Number of infusions/year median (range) | 38.0 (18.6–108.0) | 106.0 (94.9–143.9) | 74 (70.3–115.6) | 53.0 (48.7–67.6) | 75.0 (54.2–125.2) | 75.0 (48.7–143.9) |
| Total EDs in extension, median (range) | 101.5 (13–176) | 168 (11–621) | 129 (23–450) | 163 (9–328) | 348.5 (46–584) | 211.0 (9–621) |
| Time in extension, years median (range) | 3.2 (0.6–4.1) | 1.3 (0.1–6.0) | 1.7 (0.3–6.2) | 3.1 (0.3–6.3) | 4.2 (0.5–6.2) | 3.2 (0.1–6.3) |
Abbreviations: ED, exposure day; FVIII, factor VIII.
a
Patients who switched regimens after a week of first infusion in the extension period.