Table 1.
Participants’ Sociodemographic, Clinical, and Neurocognitive Characteristics
| Patients | Proxies | |
|---|---|---|
| Participants, N | 81 | 81 |
| Sex (male), N (%) | 32 (39.5%) | 32 (39.5%) |
| Age, mean (SD) | 58.2 (11.7) | 57.7 (11.7) |
| Level of education [1–8], median [range] | 3 [1–8] | 4 [1–7] |
| Type of proxy, N (%) | ||
| Partner | 60 (74.1%) | |
| Other (e.g. parent/child/sibling) | 21 (25.9%) | |
| Duration relationship (in yrs), mean (SD) | 32.9 (14.20) | |
| Tumor type, N (%) | ||
| Glioma | 43 (53.1%) | |
| Diffuse astrocytoma, IDH-mutant + 1p/19q noncodeleted | 2 (4.7%) | |
| Diffuse astrocytoma, IDH-mutant + unknown 1p/19q-codeletion | 2 (4.7%) | |
| Oligodendroglioma, IDH-mutant + 1p/19q-codeleted | 2 (4.7%) | |
| Diffuse astrocytoma, IDH-wildtype | 1 (2.3%) | |
| Diffuse astrocytoma, NOS | 11 (25.6%) | |
| Anaplastic astrocytoma, IDH-mutant | 1 (2.3%) | |
| Anaplastic oligodendroglioma, 1p/19p-codeleted | 4 (9.3%) | |
| Anaplastic glioma, NOS | 2 (4.7%) | |
| Glioblastoma, IDH-mutant | 1 (2.3%) | |
| Glioblastoma, IDH-wildtype | 10 (23.3%) | |
| Glioblastoma, NOS | 7 (16.3%) | |
| Brain metastases | 38 (46.9%) | |
| 1-3 brain metastases | 21 (25.9%) | |
| >3 brain metastases | 17 (21.0%) | |
| Tumor location, N (%) | ||
| Frontal | 24 (29.6%) | |
| Temporal | 12 (14.8%) | |
| Occipital | 5 (6.2%) | |
| Parietal | 8 (9.9%) | |
| Multiple | 29 (35.8%) | |
| Other | 2 (2.5%) | |
| Unreported | 1 (1.2%) | |
| KPS score, median [range] | 80 [40-100] | |
| Subjective neurocognitive complaints (MOS COG–R), median [range] | 29 [6-36] | |
| Above average subjective neurocognitive complaints (MOS COG–R), N (%) | 56 (69.1%) | |
| Treatment status (active anti-tumor treatment), N (%) | 24 (29.6%) | |
| Neurocognitively impaired, N (%) | 37 (45.7%) | |
| Direct recall impaired, N (%) | 21 (25.9%) | |
| Delayed recall impaired, N (%) | 25 (30.9%) | |
| Recognition discrimination impaired, N (%) | 8 (9.9% | |
| Information processing speed impaired, N (%) | 22 (27.2%) | |
| Cognitive flexibility impaired, N (%) | 45 (55.6%) | |
| Verbal fluency impaired, N (%) | 18 (22.2%) |
N, number; SD, standard deviation; yrs, years; LGG, low grade glioma; HGG, high grade glioma; KPS, Karnofsky Performance Score; MOS COG–R, Medical Outcomes Study Cognitive Functioning Scale–Revised.