FIGURE 4.

Telmisartan increases the PPAR‐γ expression, enhances the overall lipid oxidation, and upregulates the key enzyme, HADHA. (A) Western blots show with telmisartan treatment, the protein levels of PPAR‐γ are increased in both U87 and U251 cells. Tubulin is served as a control. (B) The representative fluoresces pictures show the overall lipid oxidation of U87 cells with telmisartan treatment or with DMSO only. (C) FACS quantifications of HADHA expression level. Cells are first gated as singlets and then HADHA⁺ (FITC⁺) cells. Red line strands for cells treated with vehicle (DMSO) and green line strands for cell treated with telmisartan. The bar chat shows the mean fluoresce intensity (MFI); the error bar represents SD; *p < 0.05