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. 2021 Jul 30;48(1):e12751. doi: 10.1111/nan.12751

FIGURE 2.

FIGURE 2

NOTCH3 cys variants in EGFr 7–34 are also associated with a lower NOTCH3 score in brain. (A) Example vessels from skin and brain tissue of a deceased CADASIL patient with a NOTCH3 cys variant in EGFr 1–6 and a deceased patient with a NOTCH3 cys variant in EGFr 7–34. (B) In both skin and brain vessels, the NOTCH3 score was lower in the EGFr 7–34 group compared to the EGFr 1–6 group. Data represent median ± interquartile range. (C) Correlation between the NOTCH3 score in skin and brain