TABLE 2.
Influence of carbon source on lovastatin productiona
| C sourcesb | Initial C source concn (g liter−1)b | Residual C source concn (g liter−1)b | Residual glutamic acid concn (g liter−1) | Lovastatin production (mg liter−1) |
|---|---|---|---|---|
| Glucose | 20 | 0 | 0 | 37 |
| Glucose | 45 | 0 | 0.4 | 35 |
| Glucose | 70 | 0 | 2.5 | <2 |
| Lactose | 45 | 6.3 | 0 | 25 |
| Glycerol | 20 | 0.3 | 0.2 | 6 |
| Ethanol | 20 | 8.1 | 4.4 | 4 |
| Lactose plus glucose | 20 and 20 | 11.3 and 0 | 0.4 | 54 |
| Glycerol plus glucose | 20 and 20 | 0.3 and 0 | 1.4 | 33 |
| Ethanol plus glucose | 20 and 20 | 12.2 and 0 | 0.3 | 14 |
a
After cultivation for 160 h in shake flask in chemically defined medium with glutamic acid (9.8 g liter−1) as N source (supplied as mono-hydrate sodium glutamate).
b
Respective concentrations are indicated when two substrates were used.