. 2021 Jun 7;1498(1):116–132. doi: 10.1111/nyas.14610

Table 3.

Coefficient estimates from a nonlinear mixed‐effects model with repeated measures predicting infant cognitive development between 2 and 52 weeks

	MSEL ^a gross motor				MSEL ^a fine motor				MSEL ^a visual reception				MSEL ^a receptive language				MSEL ^a expressive language
	Est	SE	t	P	Est	SE	t	P	Est	SE	t	P	Est	SE	t	P	Est	SE	t	P
Intercept	50.73	0.80	63.24	0.00	52.92	0.81	64.96	0.00	48.51	0.89	54.54	0.00	38.35	0.91	42.11	0.00	37.48	0.68	55.18	0.00
Milk thiamine at 2 weeks	−0.00	0.00	−0.67	0.50	0.00	0.00	0.75	0.46	−0.00	0.00	−0.62	0.54	0.01	0.00	2.95	0.00	0.01	0.00	2.87	0.01
Time
2–52 weeks	13.52	0.83	16.14	0.00	19.32	0.84	22.86	0.00	25.21	0.94	26.81	0.00	8.53	0.96	8.89	0.00	−0.21	0.74	−0.28	0.77
12–52 weeks	7.89	0.84	−9.31	0.00	14.56	0.86	16.94	0.00	17.60	0.96	18.37	0.00	1.07	0.97	1.10	0.27	3.00	0.75	4.00	0.00
24–52 weeks	0.05	0.81	−0.07	0.95	11.93	0.83	14.21	0.00	2.92	0.99	2.95	0.00	−10.78	0.95	11.40	0.00	−6.31	0.72	−8.82	0.00
Tx thiamine dosage ^b	−0.07	0.12	−0.61	0.54	0.16	0.12	1.26	0.21	−0.16	0.13	−1.17	0.24	−0.03	0.14	−0.24	0.81	−0.12	0.10	−1.16	0.25
Time ^* Tx thiamine dosage
2–52 weeks ^* dosage level	0.09	0.16	0.55	0.58	0.12	0.16	0.77	0.45	0.16	0.18	0.90	0.37	0.01	0.18	0.08	0.94	0.14	0.14	1.04	0.30
12–52 weeks ^* dosage level	0.15	0.16	0.89	0.37	0.17	0.17	1.01	0.31	0.09	0.18	0.47	0.64	0.22	0.18	1.22	0.23	0.21	0.14	1.47	0.14
24–52 weeks ^* dosage level	0.09	0.16	0.57	0.57	0.04	0.16	0.26	0.80	0.08	0.19	0.44	0.66	0.43	0.18	2.37	0.02	0.30	0.13	2.13	0.03

Note: Table results are based on nonlinear mixed‐effects models with repeated measures. Significant effects are presented in bold font.

^{^a}

MSEL, Mullen Scales of Early Learning. All MSEL scores are standardized T‐scores, with a mean of 50 and SD of 10.

^{^b}

Tx thiamine dosage = thiamine supplementation dosages used in treatment trial (0, 1.2, 2.4, and 10 mg/daily) between 2 and 24 weeks.