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. 2022 Jun 30;14:894994. doi: 10.3389/fnagi.2022.894994

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Copyright © 2022 Hurley, Urra, Garduno, Bruno, Kimbell, Wilkinson, Marino-Buslje, Ezquer, Ezquer, Aburto, Poulin, Vasquez, Deacon, Avila, Altimiras, Whitney Vanderklish, Zampieri, Angione, Constantino, Holmes, Coba, Xu and Cogram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Novel degu Apoe (odApoe) mutation: whole-genome sequencing. (A) At position 213, there are three possible residues: glutamic acid (Glu: E), glutamine (Gln: Q), or lysine (Lys: K). Variants 1 and 2 are 213 E>Q and 213 E>K, respectively. The neighboring silent SNP was located 109 base pairs upstream of the missense variant (shown in pink). (B) The genotype frequency in 137 wild degu. (C) Allele association with AD-like pathology in degu. (D) There was a significant difference in the association of the variants E213K and 213 E>Q with AD-like burrowing behavior (Mann–Whitney U test, P < 0.001)