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. 2022 Jun 17;1(3):pgac062. doi: 10.1093/pnasnexus/pgac062

Figure 1.

Figure 1.

Average IgG and IgM antibody signals to all glycans. (A) Box and whisker plots of the average array signals (log-transformed base 2) to all array components for IgG and IgM antibodies from control and COVID-19 serum samples. Mean IgG of control samples was 9.21 raw fluorescence units (RFU) on a log2 scale. Mean IgG signal for the Raybiotech COVID-19 cohort was 9.30, and the mean of NIH COVID-19 cohort was 8.90. An unpaired t test with Welch's correction showed no significant difference between mean IgG values of the controls and Raybiotech cohort and a small difference between the controls and NIH COVID-19 cohort IgG values (*, P = 0.0250). Mean IgM of controls was 12.41. Mean IgM of Raybtioech COVID-19 cohort was 11.21. Mean IgM of NIH COVID-19 cohort was 10.83. Unpaired t test with Welch's correction for mean IgM values was significant for both COVID-19 cohorts compared to controls (****, P < 0.0001). (B) Box and whisker plots of the average array signals for IgM and IgG of a select age range of patients. ns, not significant. Boxes depict quartiles and whiskers depict the min and max.