Table 1. Univariate associations and multivariable models of overall and recurrence free survival in patients with stage I and II NSCLC undergoing lobectomy.
Variables associated with survival on univariate analysis (P<0.1; in bold) were included in multivariable analyses. Only variables included in the final multivariable models are shown.
| Variable | Univariate | Multivariable | |||
|---|---|---|---|---|---|
| Overall survival HR (95% CI) | Recurrence free survival | Overall survival HR (95% CI) | Recurrence free survival | ||
| Age | 67 ± 10.4 | 1.05 (1.03 – 1.06) | 1.01 (0.99 – 1.03) | 1.04(1.02–1.06) | |
| Sex (Female vs. male) | 305(59.5%) Female | 0.57 (0.41 – 0.80) | 0.65 (0.43 – 1.00) | 0.64(0.44 – 0.92) | |
| Race (White vs. others) | 462 (90.1%) White | 0.70 (0.36 – 1.31) | 0.40 (0.15 – 1.10) | ||
| DLCO | 77.3 ± 21.2 | 0.99 (0.98 – 1.00) | 0.99 (0.98 – 1.00) | 0.99(0.98–1.00) | |
| ASA score (High vs. Low) | 248 (48.3%) HIgh | 2.07 (1.47 – 2.90) | 1.49 (0.97 – 2.28) | 1.55(1.07 – 2.24) | |
| BMI | 27.2 ± 5.6 | 1.01 (0.98 – 1.04) | 1.01 (0.97 – 1.05) | ||
| VFI | 0.45 ± 0.14 | 7.30 (3.18 – 24.08) | 5.19 (1.14 – 23.69) | 4.51(0.93 – 21.76) | |
| Tumor grade (High vs. Low) | 181 (35.3%) High | 1.62 (1.16 – 2.26) | 1.95 (1.28 – 2.98) | 1.64(1.16–2.32) | 1.88(1.22 – 2.88) |
| Tumor stage (II vs. I) | 140 (27.3%) Stage II | 1.21 (0.84 – 1.74) | 2.19 (1.43 – 3.36) | 1.97(1.28 – 3.04) | |
| Histology Adeno vs. other SqCC vs. other | Adeno 317 (61.8%) SqCC 139 (27.1%) Other 57 (11.1%) | 0.81 (0.64 – 1.03) 1.33 (1.02 – 1.72) | 1.04 (0.76 – 1.42) 1.02 (0.71 – 1.47) | ||
| Smoking status Current vs. Never Former vs. Never | Never - 52 (10.1%) Former - 175 (34.1%) Current - 286 (55.8%) | 0.79 (0.53 – 1.17) 1.03 (0.78 – 1.37) | 0.94 (0.59 – 1.49) 1.01 (0.72 – 1.42) | ||
BMI = Body Mass Index; VFI = Visceral Fat Index; DLCO = Diffusion capacity for carbon monoxide; ASA – American Society of Anesthesiology; Adeno = Adenocarcinoma; SqCC – Squamous cell carcinoma.