Table 2.
Association of High-Shear BV and Mortality Among COVID-19 Patients
| High-Shear BV Quartile 1 (Lowest) (n = 1,405) | High-Shear BV Quartile 2 (n = 1,406) | High-Shear BV Quartile 3 (n = 1,405) | High-Shear BV Quartile 4 (Highest) (n = 1,405) | P for Trend | |
|---|---|---|---|---|---|
| BV range, cP | 3.01-4.00 | 4.00-4.24 | 4.24-4.53 | 4.53-9.86 | |
| Person-days | 12,833 | 13,769 | 13,364 | 14,105 | |
| In-hospital deaths | 193 | 238 | 260 | 332 | |
| aHR (95% CI)a | 1.00 (reference) | 1.27 (1.04-1.54) | 1.23 (1.02-1.49) | 1.53 (1.27-1.84) | <0.001 |
| aHR (95% CI)b | 1.00 (reference) | 1.21 (0.97-1.52) | 1.16 (0.92-1.45) | 1.50 (1.20-1.87) | <0.001 |
| aHR (95% CI)c | 1.00 (reference) | 1.17 (0.79-1.72) | 1.14 (0.77-1.68) | 1.60 (1.09-2.35) | 0.020 |
The linear modeling results were an aHR of 1.36 (95% CI: 1.19-1.55; P < 0.001) per 1-cP increase and an aHR of 1.18 (95% CI: 1.10-1.26; P < 0.001) per IQR (0.53 cP) increase.
aHR = adjusted HR; COVID-19 = coronavirus disease-2019; other abbreviations as in Table 1.
aHRs calculated by Cox proportional hazards regression after adjustments for age, sex; hospital site; race; history of HTN, DM, CKD, and CAD; in-hospital statin use; anticoagulation therapy; date of admission; and measure of initial oxygen support.
aHRs calculated by Cox proportional hazards regression after adjustments for age; sex; hospital site; race; history of HTN, DM, CKD, and CAD; in-hospital statin use; anticoagulation therapy; date of admission; measure of initial oxygen support; and initial lab data (WBC, CRP, and D-dimer).
Additionally adjusted for interleukin-6 and excluded CRP due to collinearity.