TABLE1.

DNA nanoparticles in chemotherapy.

Chemotherapeutic Drugs	DNA Nanostructures	Modification	Effect	Ref
Doxorubicin	DNA tetrahedron	Folate receptor	Apoptosis promoting	Zhang et al. (2017b)
		KLA peptide	Drug delivery and apoptosis promoting	Yan et al. (2020)
		AS1411 + MUC1 aptamer	Breast cancer cell imaging and drug delivery	Liu et al. (2018a)
		Affibody	Selectivity and inhibition of breast cancer cells	Zhang et al. (2017c)
	DNA octahedron	Folate	Selective targeting	Raniolo et al. (2018)
	DNA icosahedron	MUC1 aptamer	Efficient and specific internalization for killing epithelial cancer cells	Chang et al. (2011)
	DNA NFs	Sgc8	Nuclease resistance and binding of different functional moieties	Lv et al. (2015)
	DNA triangle and tube	-	Increased doxorubicin cellular internalization and elevated susceptibility to drug-resistant adenocarcinoma cells	Bertrand et al. (2014)
	RCA-based nanostructures	Imotif sequence, Sgc8	pH-Responsive Drug Delivery	Zhao et al. (2018)
Daunorubicin	DNA nanorod	-	Circumvent drug-resistance mechanisms in a leukemia model	Halley et al. (2016)
Platinum	DNA tetrahedron	-	Targeted platinum drug delivery	Wu et al. (2019)
	DNA icosahedron	Telomerase-Responsive	Precise delivery of platinum nanodrugs to cisplatin-resistant cancer	Ma et al. (2018)