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. 2022 Jul 4;12:904865. doi: 10.3389/fonc.2022.904865

Table 3.

Functional enrichment analysis of mRNAs in the ceRNA network in SCLC.

ID Description Ontology Bg Ratio p value Adjusted p Genes symbol* Count
GO:0043312 neutrophil degranulation BP 485/18670 1.843E-06 9.114E-04 CFD/FCN1/FGR/GAA/ITGAL/ITGAX/ITGB2/TCIRG1/CD93/NFAM1 10
GO:0002283 neutrophil activation involved in immune response BP 488/18670 1.948E-06 9.114E-04 CFD/FCN1/FGR/GAA/ITGAL/ITGAX/ITGB2/TCIRG1/CD93/NFAM1 10
GO:0042119 neutrophil activation BP 498/18670 2.336E-06 9.114E-04 CFD/FCN1/FGR/GAA/ITGAL/ITGAX/ITGB2/TCIRG1/CD93/NFAM1 10
GO:0002446 neutrophil-mediated immunity BP 499/18670 2.378E-06 9.114E-04 CFD/FCN1/FGR/GAA/ITGAL/ITGAX/ITGB2/TCIRG1/CD93/NFAM1 10
GO:0007229 integrin-mediated signalling pathway BP 103/18670 1.545E-05 4.738E-03 FGR/ITGAL/ITGAX/ITGB2/ADAM15 5
GO:0050663 cytokine secretion BP 240/18670 8.892E-05 2.272E-02 FCN1/FGR/NOTCH1/TCIRG1/CD244/NLRP12 6
GO:0030198 extracellular matrix organization BP 368/18670 1.237E-04 2.467E-02 ITGAL/ITGAX/ITGB2/NOTCH1/ADAM15/GREM1/ADAMTSL4 7
GO:0050900 leukocyte migration BP 499/18670 1.287E-04 2.467E-02 CSF3R/ITGAL/ITGAX/ITGB2/GREM1/CD244/MYO1G/NLRP12 8
GO:0043062 extracellular structure organization BP 422/18670 2.861E-04 4.873E-02 ITGAL/ITGAX/ITGB2/NOTCH1/ADAM15/GREM1/ADAMTSL4 7
GO:0101003 ficolin-1-rich granule membrane CC 61/19717 8.873E-07 6.558E-05 GAA/ITGAX/ITGB2/TCIRG1/CD93 5
GO:0101002 ficolin-1-rich granule CC 185/19717 1.017E-06 6.558E-05 CFD/FCN1/GAA/ITGAX/ITGB2/TCIRG1/CD93 7
GO:0030667 secretory granule membrane CC 298/19717 2.154E-06 9.263E-05 APLP2/GAA/ITGAL/ITGAX/ITGB2/TCIRG1/CD93/NFAM1 8
GO:0070821 tertiary granule membrane CC 73/19717 5.888E-05 1.899E-03 GAA/ITGAX/ITGB2/CD93 4
GO:0008305 integrin complex CC 31/19717 9.721E-05 2.370E-03 ITGAL/ITGAX/ITGB2 3
GO:0070820 tertiary granule CC 164/19717 1.106E-04 2.370E-03 GAA/ITGAX/ITGB2/TCIRG1/CD93 5
GO:0098636 protein complex involved in cell adhesion CC 34/19717 1.286E-04 2.370E-03 ITGAL/ITGAX/ITGB2 3
GO:0005774 vascular membrane CC 412/19717 1.184E-03 1.910E-02 ABCA2/GAA/TCIRG1/AHNAK/ATG16L2/NFAM1 6
GO:0031256 leading edge membrane CC 170/19717 1.476E-03 1.988E-02 FGR/PSD4/MYO1G/FGD2 4
GO:0001726 Ruffle CC 172/19717 1.541E-03 1.988E-02 FGR/MEFV/PSD4/FGD2 4
GO:0035579 specific granule membrane CC 91/19717 2.324E-03 2.725E-02 ITGAL/ITGB2/CD93 3
GO:0032587 ruffle membrane CC 94/19717 2.549E-03 2.740E-02 FGR/PSD4/FGD2 3
GO:0005765 lysosomal membrane CC 354/19717 3.536E-03 3.297E-02 ABCA2/GAA/TCIRG1/AHNAK/NFAM1 5
GO:0098852 lytic vacuole membrane CC 355/19717 3.578E-03 3.297E-02 ABCA2/GAA/TCIRG1/AHNAK/NFAM1 5

GO, gene ontology; BP, biological process; CC, cellular component; KEGG, Kyoto Encyclopaedia of Genes and Genomes; ceRNA, competing endogenous RNA; circRNA, circular RNAs; lncRNA, long noncoding RNA; miRNA, microRNA; mRNA, messenger RNA; SCLC, small cell lung cancer; Bg, background. *The full name of gene symbols is available in Table 2 .