Table 4.
Functional enrichment analysis and pathway results of lncRNAs in the ceRNA network.
| ID | Description | Ontology | Bg Ratio | p value | Adjusted p |
|---|---|---|---|---|---|
| GO:0050911 | Detection of chemical stimulus involved in sensory perception of smell | BP | 0.0252 | 2.5259E-19 | 1.5494E-15 |
| GO:0032199 | Reverse transcription involved in RNA-mediated transposition | BP | 0.0486 | 2.0772E-15 | 6.3707E-12 |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | BP | 0.058 | 2.5433E-14 | 5.2002E-11 |
| GO:0007186 | G-protein coupled receptor signalling pathway | BP | 0.0406 | 7.6252E-13 | 1.1693E-09 |
| GO:0097252 | Oligodendrocyte apoptotic process | BP | 0.039 | 1.6472E-11 | 2.0208E-08 |
| GO:0006289 | Nucleotide-excision repair | BP | 0.0402 | 4.2385E-11 | 4.3332E-08 |
| GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | BP | 0.0399 | 8.0612E-11 | 6.7949E-08 |
| GO:0000733 | DNA strand renaturation | BP | 0.0395 | 8.8620E-11 | 6.7949E-08 |
| GO:0007569 | Cell aging | BP | 0.0397 | 1.1273E-10 | 7.6831E-08 |
| GO:0030308 | Negative regulation of cell growth | BP | 0.0447 | 1.8945E-10 | 1.1621E-07 |
| GO:0007275 | Multicellular organism development | BP | 0.0664 | 2.2891E-08 | 1.2765E-05 |
| GO:0006310 | DNA recombination | BP | 0.0325 | 3.6143E-08 | 1.8475E-05 |
| GO:0006278 | RNA-dependent DNA biosynthetic process | BP | 0.0088 | 4.2840E-08 | 2.0214E-05 |
| GO:0032197 | Transposition, RNA-mediated | BP | 0.0081 | 6.9777E-06 | 3.0572E-03 |
| GO:0009987 | Cellular process | BP | 0.003 | 1.2068E-05 | 4.9352E-03 |
| GO:0006259 | DNA metabolic process | BP | 0.0054 | 1.4735E-05 | 5.6492E-03 |
| GO:0007156 | Homophilic cell adhesion via plasma membrane adhesion molecules | BP | 0.0098 | 7.3718E-05 | 2.6599E-02 |
| GO:0016043 | Cellular component organisation | BP | 0.0064 | 7.8691E-05 | 2.6816E-02 |
| GO:0044238 | Primary metabolic process | BP | 0.0027 | 1.3610E-04 | 4.3939E-02 |
| GO:0048741 | Skeletal muscle fibre development | BP | 0.0141 | 1.6591E-04 | 4.8714E-02 |
| GO:0003338 | Metanephros morphogenesis | BP | 0.001 | 1.7472E-04 | 4.8714E-02 |
| GO:0070307 | Lens fibre cell development | BP | 0.001 | 1.7472E-04 | 4.8714E-02 |
| GO:0044424 | Intracellular part | CC | 0.007 | 1.7884E-07 | 1.6189E-04 |
| GO:0043229 | Intracellular organelle | CC | 0.0019 | 1.2468E-06 | 4.2980E-04 |
| GO:0005886 | Plasma membrane | CC | 0.1378 | 1.4243E-06 | 4.2980E-04 |
| GO:0044446 | Intracellular organelle part | CC | 0.0032 | 2.8392E-06 | 6.4257E-04 |
| GO:0098588 | Bounding membrane of organelle | CC | 0.0086 | 5.0429E-05 | 9.1302E-03 |
| GO:0044456 | Synapse part | CC | 0.0013 | 1.3285E-04 | 1.9921E-02 |
| GO:0005739 | Mitochondrion | CC | 0.0821 | 1.6615E-04 | 1.9921E-02 |
| GO:0005796 | Golgi lumen | CC | 0.0066 | 1.7604E-04 | 1.9921E-02 |
| GO:0005578 | Proteinaceous extracellular matrix | CC | 0.0098 | 2.3813E-04 | 2.3264E-02 |
| GO:0016021 | Integral component of membrane | CC | 0.2479 | 2.5699E-04 | 2.3264E-02 |
| GO:0097546 | Ciliary base | CC | 0.0041 | 5.4612E-04 | 4.4944E-02 |
| GO:0005887 | Integral component of plasma membrane | CC | 0.066 | 6.2753E-04 | 4.7340E-02 |
| GO:0003964 | RNA-directed DNA polymerase activity | MF | 0.0534 | 7.1861E-20 | 1.0143E-16 |
| GO:0004984 | Olfactory receptor activity | MF | 0.0249 | 1.0694E-19 | 1.0143E-16 |
| GO:0004930 | G-protein coupled receptor activity | MF | 0.0316 | 4.2156E-17 | 2.6656E-14 |
| GO:0009036 | Type II site-specific deoxyribonuclease activity | MF | 0.0479 | 1.2775E-16 | 6.0586E-14 |
| GO:0005507 | Copper ion binding | MF | 0.0408 | 1.0171E-10 | 3.8588E-08 |
| GO:0005488 | Binding | MF | 0.0105 | 1.9980E-10 | 6.3171E-08 |
| GO:0043167 | Ion binding | MF | 0.0116 | 3.3737E-07 | 9.1428E-05 |
| GO:0005549 | Odorant binding | MF | 0.0056 | 1.5499E-06 | 3.6752E-04 |
| hsa04740 | Olfactory transduction | KEGG | 0.0598 | 8.0910E-40 | 2.2399E-37 |
| hsa04080 | Neuroactive ligand-receptor interaction | KEGG | 0.0385 | 5.7920E-08 | 8.0173E-06 |
| hsa05033 | Nicotine addiction | KEGG | 0.0054 | 2.1224E-04 | 1.9585E-02 |
| hsa04973 | Carbohydrate digestion and absorption | KEGG | 0.0076 | 5.8461E-04 | 3.3090E-02 |
| hsa04974 | Protein digestion and absorption | KEGG | 0.012 | 5.9763E-04 | 3.3090E-02 |
GO, gene ontology; BP, biological process; CC, cellular component; KEGG, Kyoto Encyclopaedia of Genes and Genomes; ceRNA, competing endogenous RNA; circRNA, circular RNAs; lncRNA, long noncoding RNA; miRNA, microRNA; mRNA, messenger RNA; Bg, background.