Table 6.
Functional enrichment analysis of miRNAs in the ceRNA network.
| ID | Description | Ontology | Bg Ratio | p value | Adjusted p |
|---|---|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | BP | 0.0921 | 8.5782E-11 | 5.7934E-07 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | BP | 0.0565 | 1.5250E-08 | 5.1498E-05 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | BP | 0.0664 | 2.6517E-08 | 5.9696E-05 |
| GO:0060348 | bone development | BP | 0.0174 | 6.6166E-08 | 1.0284E-04 |
| GO:0017144 | drug metabolic process | BP | 0.0187 | 8.6063E-08 | 1.0284E-04 |
| GO:0017187 | peptidyl-glutamic acid carboxylation | BP | 0.0179 | 9.1359E-08 | 1.0284E-04 |
| GO:0042373 | vitamin K metabolic process | BP | 0.0177 | 2.6291E-07 | 2.5366E-04 |
| GO:0007250 | activation of NF-kappa-inducing kinase activity | BP | 0.0124 | 3.1140E-07 | 2.5645E-04 |
| GO:0007156 | hemophilic cell adhesion via plasma membrane adhesion molecules | BP | 0.0098 | 3.4174E-07 | 2.5645E-04 |
| GO:0032743 | positive regulation of interleukin 2 production | BP | 0.0125 | 6.9433E-07 | 4.6893E-04 |
| GO:2000679 | positive regulation of transcription regulatory region DNA binding | BP | 0.017 | 1.4950E-06 | 9.1787E-04 |
| GO:0031293 | membrane protein intracellular domain proteolysis | BP | 0.0124 | 2.1866E-06 | 1.2306E-03 |
| GO:0002756 | MyD88-independent toll-like receptor signalling pathway | BP | 0.0116 | 3.2308E-06 | 1.6785E-03 |
| GO:0000187 | activation of MAPK activity | BP | 0.0213 | 5.9088E-06 | 2.8504E-03 |
| GO:0002726 | positive regulation of T cell cytokine production | BP | 0.0124 | 9.3027E-06 | 4.1885E-03 |
| GO:0070555 | response to interleukin 1 | BP | 0.0098 | 1.0189E-05 | 4.2601E-03 |
| GO:0051865 | protein auto-ubiquitination | BP | 0.0143 | 1.0723E-05 | 4.2601E-03 |
| GO:0045672 | positive regulation of osteoclast differentiation | BP | 0.0125 | 1.3074E-05 | 4.7509E-03 |
| GO:0001932 | regulation of protein phosphorylation | BP | 0.003 | 1.4009E-05 | 4.7509E-03 |
| GO:0070534 | protein K63-linked ubiquitination | BP | 0.0182 | 1.4069E-05 | 4.7509E-03 |
| GO:0031398 | positive regulation of protein ubiquitination | BP | 0.0121 | 2.6984E-05 | 8.2836E-03 |
| GO:0034162 | toll-like receptor 9 signalling pathway | BP | 0.0121 | 2.6984E-05 | 8.2836E-03 |
| GO:0070423 | nucleotide-binding oligomerisation domain containing signalling pathway | BP | 0.0175 | 2.8472E-05 | 8.3605E-03 |
| GO:0043507 | positive regulation of JUN kinase activity | BP | 0.0139 | 4.0463E-05 | 1.1386E-02 |
| GO:0030574 | collagen catabolic process | BP | 0.0023 | 4.2766E-05 | 1.1553E-02 |
| GO:0071222 | cellular response to lipopolysaccharide | BP | 0.0118 | 5.4294E-05 | 1.4070E-02 |
| GO:0002755 | MyD88-dependent toll-like receptor signalling pathway | BP | 0.0181 | 5.6249E-05 | 1.4070E-02 |
| GO:0046513 | ceramide biosynthetic process | BP | 0.0096 | 6.7342E-05 | 1.6134E-02 |
| GO:0035019 | somatic stem cell population maintenance | BP | 0.0075 | 6.9279E-05 | 1.6134E-02 |
| GO:0001707 | mesoderm formation | BP | 0.0013 | 8.3053E-05 | 1.8697E-02 |
| GO:0007596 | blood coagulation | BP | 0.0236 | 9.1112E-05 | 1.9850E-02 |
| GO:0050870 | positive regulation of T cell activation | BP | 0.0067 | 1.5077E-04 | 3.1820E-02 |
| GO:0007155 | cell adhesion | BP | 0.0111 | 1.5634E-04 | 3.1997E-02 |
| GO:0015886 | heme transport | BP | 0.0035 | 1.6785E-04 | 3.2879E-02 |
| GO:0043065 | positive regulation of apoptotic process | BP | 0.028 | 1.7039E-04 | 3.2879E-02 |
| GO:0045059 | positive thymic T cell selection | BP | 0.0023 | 1.9247E-04 | 3.6108E-02 |
| GO:0035023 | regulation of Rho protein signal transduction | BP | 0.0039 | 2.1384E-04 | 3.9032E-02 |
| GO:0051092 | positive regulation of NF-kappa B transcription factor activity | BP | 0.026 | 2.2701E-04 | 4.0346E-02 |
| GO:0031410 | cytoplasmic vesicle | CC | 0.014 | 8.1251E-07 | 6.2029E-04 |
| GO:0005789 | endoplasmic reticulum membrane | CC | 0.0602 | 1.2645E-06 | 6.2029E-04 |
| GO:0010008 | endosome membrane | CC | 0.0227 | 1.8113E-06 | 6.2029E-04 |
| GO:0005829 | cytosol | CC | 0.1935 | 7.5017E-06 | 1.9267E-03 |
| GO:0034704 | calcium channel complex | CC | 0.0008 | 5.8805E-05 | 1.2083E-02 |
| GO:0005811 | lipid droplet | CC | 0.012 | 7.5151E-05 | 1.2868E-02 |
| GO:0035631 | CD40 receptor complex | CC | 0.0098 | 1.0108E-04 | 1.3848E-02 |
| GO:0009898 | cytoplasmic side of plasma membrane | CC | 0.0116 | 1.0783E-04 | 1.3848E-02 |
| GO:0005667 | transcription factor complex | CC | 0.0095 | 3.8115E-04 | 4.3509E-02 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | MF | 0.0684 | 1.2784E-14 | 2.7816E-11 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | MF | 0.0261 | 6.2083E-13 | 6.7539E-10 |
| GO:0046872 | metal ion binding | MF | 0.1355 | 1.8538E-08 | 1.3445E-05 |
| GO:0031996 | thioesterase binding | MF | 0.0128 | 1.6534E-07 | 7.5276E-05 |
| GO:0031624 | ubiquitin conjugating enzyme binding | MF | 0.0136 | 1.7299E-07 | 7.5276E-05 |
| GO:0042826 | histone deacetylase binding | MF | 0.0191 | 3.5880E-07 | 1.3011E-04 |
| GO:0047057 | vitamin-K-epoxide reductase (warfarin-sensitive) activity | MF | 0.0174 | 4.3664E-07 | 1.3572E-04 |
| GO:0043422 | protein kinase B binding | MF | 0.0122 | 5.3369E-07 | 1.4515E-04 |
| GO:0031435 | mitogen-activated protein kinase binding | MF | 0.0125 | 2.4614E-06 | 5.9505E-04 |
| GO:0005164 | tumour necrosis factor receptor binding | MF | 0.0133 | 4.8342E-06 | 1.0518E-03 |
| GO:0050291 | sphingosine N-acyltransferase activity | MF | 0.0083 | 2.3602E-05 | 4.6685E-03 |
| GO:0003682 | chromatin binding | MF | 0.0168 | 3.5302E-05 | 6.4008E-03 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MF | 0.0219 | 4.3610E-05 | 7.2989E-03 |
| GO:0005096 | GTPase activator activity | MF | 0.0123 | 1.0248E-04 | 1.5927E-02 |
| GO:0031625 | ubiquitin protein ligase binding | MF | 0.0317 | 1.2898E-04 | 1.8708E-02 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | MF | 0.009 | 1.5448E-04 | 2.1007E-02 |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | MF | 0.0242 | 1.9703E-04 | 2.5217E-02 |
| GO:0008270 | zinc ion binding | MF | 0.0636 | 2.6201E-04 | 3.1672E-02 |
| GO:0001047 | core promoter binding | MF | 0.0109 | 4.3480E-04 | 4.9792E-02 |
GO, gene ontology; BP, biological process; CC, cellular component; ceRNA, competing endogenous RNA; miRNA, microRNA; Bg, background.